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| URL | https://doi.org/10.18429/JACoW-HIAT2025-FRA04 |
|---|---|
| Title | The SPES-ISOLPHARM beamline for the production of medical radionuclides at INFN-LNL |
| Authors |
|
| Abstract | The ISOLPHARM project, headed by the Legnaro National Laboratories of the Italian National Institute for Nuclear Physics (INFN-LNL), has the aim of developing innovative radiopharmaceuticals based on the radionuclides produced at the SPES Isotope Separation On-Line (ISOL) facility. Regarding the infrastructure, in late 2024 a key milestone of SPES was achieved: the production of the first radioactive ion beam by irradiating a silicon carbide target with an intermediate-energy proton beam. Moreover, the ISOLPHARM implantation station for radionuclide delivery to users, IRIS, is currently being installed online. Since its beginning in 2014, ISOLPHARM has built a broad network of universities, hospitals and research centers. The beta emitter silver-111, in particular, obtainable using uranium carbide targets, has aroused a great interest in the collaboration as a theranostic candidate for targeted radionuclide therapy; a dedicated experimental campaign performed the first in-vitro tests and in-vivo imaging in 2024. This contribution will provide an overview on the status of the beamline and on the main results achieved by the preclinical experiments involving silver-111. |
| Paper | download: FRA04.pdf |
| Cite | BibTeX, LaTeX, Text/Word, RIS, EndNote |
| Conference | 16th International Conference on Heavy Ion Accelerator Technology |
| Series | |
| Location | Michigan State University, East Lansing, USA |
| Date | 22-27 Jun 2025 |
| Publisher | JACoW Publishing, Geneva, Switzerland |
| Editorial Board | Ling Wang (FRIB/MSU), Kelly Jaje (ANL), Michelle Wier (FRIB/MSU), Kent Wootton (ANL), Tong Zhang (FRIB/MSU) |
| Online ISBN | 978-3-95450-260-8 |
| Online ISSN | 2673-5547 |
| Received | 27 May 2025 |
| Revised | 22 June 2025 |
| Accepted | 22 June 2025 |
| Issued | 01 August 2025 |
| DOI | 10.18429/JACoW-HIAT2025-FRA04 |
| Pages | 299-302 |
| Copyright | Published by JACoW Publishing under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s), the published article's title, publisher, and DOI. |